Tsyr-Yan Yu
Research Fellow
| Email: | tyyu[at]pub.iams.sinica.edu.tw |
| Office: | R231 |
| Tel: | +886-2-2366-8210 |
| Lab: | 221 |
| Lab Tel: | +886-2-2366-8288 |
| NMR Spectroscopy Laboratory | |
Research Interest
1. Membrane Protein Research
2. NMR spectroscopy
3. Molecular Basis of Familial Amyloid Polyneuropathy
Research Overview
Dr. Tsyr-Yan Yu has long been dedicated to the fields of biophysics and structure biology, with a primary research focus on the interactions between membrane proteins and lipid membranes across various time scales to explore their functional implications in both physiological and pathological processes. He has also conducted in-depth investigations into how mutations in transthyretin (TTR) lead to protein misfolding and aggregation, which in turn triggers familial amyloid polyneuropathy (FAP). His work provides critical insights into disease mechanisms and essential clues for potential therapeutic strategies. Furthermore, Dr. Yu has developed innovative solid-state nuclear magnetic resonance (NMR) techniques for detecting molecular reorientational motion in organic-inorganic hybrid perovskite materials. This research has laid a vital foundation for understanding the relationship between the structure and function of next- generation optoelectronic materials.
Education
- B.S., Chemistry, 1998, National Taiwan University, Taipei, Taiwan
- M.S., Chemistry, 2000, National Taiwan University, Taipei, Taiwan
- Ph.D., Chemistry, 2008, Washington University in St. Louis, USA
Professional History
- Postdoctoral Research Associate, Washington University in St. Louis, USA (August 2008- October 2008)
- Postdoctoral Research Associate, Harvard University, USA (January 2009- October 2013)
- Assistant Research Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica, Taiwan (November 2013 – September 2020)
- Associate Research Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica, Taiwan (November 2020 – January 2026)
- Research Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica, Taiwan (January 2026 – present)
Awards & Honors
- 2020 Career Development Award, Academia Sinica
- 2017 Young Scholar Creativity and Innovation Award, Foundation for The Advancement of Outstanding Scholarship
- 2009 Fellowship, Postdoctoral Research Abroad Program, National Science Council, Taiwan
- 2008 Student Award, The 49th Experimental Nuclear Magnetic Resonance Conference
- 2004 TA Teaching Award, Washington University in St. Louis
Selected Publications
- Cheng-Chieh Lin, Shing-Jong Huang, Pei-Hao Wu, Tzu-Pei Chen, Chih-Ying Huang, Ying-Chiao Wang, Po-Tuan Chen, Denitsa Radeva, Ognyan Petrov, Vladimir M. Gelev, Raman Sankar, Chia-Chun Chen, Chun-Wei Chen*, and Tsyr-Yan Yu*, Direct Investigation of the Reorientational Dynamics of A-Site Cations in 2D Organic-Inorganic Hybrid Perovskite by Solid-State NMR, Nature Communications, 13, 1513 (2022).
- Vivien Yeh, Tsung-Yen Lee, Chung-Wen Chen, Pai-Chia Kuo, Jessie Shiue, Li-Kang Chu*, and Tsyr-Yan Yu*, Highly Efficient Transfer of 7TM Membrane Protein from Native Membrane to Covalently Circularized Nanodisc, Scientific Reports, 8, 13501 (2018).
- Orion Shih, Yi-Qi Yeh, Kuei-Fen Liao, Chun-Jen Su, Pei-Hao Wu, Richard K. Heenan, Tsyr-Yan Yu*, and U-Ser Jeng*, Membrane Charging and Swelling upon Calcium Adsorption as Revealed by Phospholipid Nanodiscs, Journal of Physical Chemistry Letters, 9, 4287 (2018).
- Yustina Yusuf, Julien Massiot, Yu-Ting Chang, Pei-Hao Wu, Vivien Yeh, Pai-Chia Kuo, Jessie Shiue*, Tsyr-Yan Yu*, Optimization of the production of covalently circularized nanodiscs and their characterization in physiological conditions, Langmuir, 34, 3525. (2018).
- Vivien Yeh, Yin Hsin, Tsung-Yen Lee, Jerry Chun Chung Chan, Tsyr-Yan Yu*, and Li-Kang Chu*, Lipids Influence the Proton Pump Activity of Photosynthetic Protein Embedded in Nanodiscs, RCS Advances 6, 88300-88305. (2016).
- Tsung-Yen Lee, Vivien Yeh, Julia Chuang, Jerry Chun Chung Chan, Li-Kang Chu, Tsyr-Yan Yu*, Tuning the Photocycle Kinetics of Bacteriorhodopsin in Lipid Nanodiscs, Biophys. J., 109(9), 1899-1906. (2015)
- Matthew T Eddy, Tsyr-Yan Yu*, Membranes, Peptides, and Disease: Unraveling the Mechanisms of Viral Proteins with Solid State Nuclear Magnetic Resonance Spectroscopy. Solid State Nuclear Magnetic Resonance, 61-62, 1-7. (2014).