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Ching-Wei Lin

Assistant Research Fellow

Ching-Wei Lin
Email: linc[at]sinica.edu.tw
Office: R338
Tel: +886-2-2362-4976
Lab: L327
Lab Tel: +886-2-2366-8253
Photonic Nanomaterials and Biomedical Imaging Lab

Research Interest

  • Short-wave infrared spectroscopy and imaging
  • Photonic nanomaterials
  • Single-walled carbon nanotubes
  • Single-photon emitters

Research Overview

Dr. Ching-Wei Lin focuses on frontier research in nano-optics and biophotonics, and is dedicated to developing innovative spectroscopic technologies to elucidate the interactions between nanomaterials

and biological systems. He pioneered short-wave infrared (short-wave infrared, SWIR)-based fluorescence flow cytometry, overcoming the limitations of conventional visible and near-infrared imaging to enable high-contrast, deep-penetration cellular analysis, thereby expanding its potential applications in biomedical imaging and immune monitoring. In parallel, Dr. Lin has conducted in-depth

investigations of the dynamic interactions between single-walled carbon nanotubes (SWCNTs) and biological systems, including cellular uptake, distribution, and biocompatibility, laying a foundation for

the safety and functionality of carbon nanotubes as drug carriers or biosensors. In addition, he has developed SWIR chiroptical spectroscopy to study structural recognition and selective interactions between chiral nanomaterials and biomolecules, further advancing the application of chiroptical technologies in nanomedicine and molecular diagnostics.

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Education

  • 2012 – 2017  PhD, Department of Chemistry, Rice University, Houston, TX, USA
  • 2007 – 2009  MS, Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan
  • 2003 – 2007  BS, Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan

Professional History

  • 2020 – present  Assistant Research Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan
  • 2017 – 2020  Postdoctoral Fellow, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA

Awards & Honors

  • Annual Best Paper Award, Chemistry (Chemical Society Located in Taipei) (2023)
  • Career Development Award, Academia Sinica (2021)
  • Career Development Award, Academia Sinica (2021)
  • Young Scholars Award, Ministry of Science and Technology in Taiwan (2019)
  • IBB Travel Grant Award, Rice University (2017)
  • The Stephen C. Hofmann Fellowship Award, Rice University (2015)
  • Outstanding Thesis Award (first place) for Graduate Students in Physical Chemistry, the Chinese Chemical Society (2009)
  • Outstanding Student of National Taiwan Normal University (2006)
Selected Publications
  • Liu, T.-I*; Wang, J.-S.; Nguyen, A.-P.; Raabe, M.; Quiroz Reyes, C. J.; Lin, C.-H.; Lin, C.-W.*, "Cytometry in the short-wave infrared", ACS Nano 2024, 18 (28), 18534–18547 
  • Lin, C.-W.#; Huang, S.#; Colangelo, M.; Chen, C.; Wong, F. N. C.; He, Y.; Berggren, K.; Belcher, A.M.*, "Surface plasmon enhanced up-conversion fluorescence in short-wave infrared for in vivo imaging of ovarian cancer" # co-first author, ACS Nano 2022, 16 (8), 12930–12940 
  • Huang, S.; Lin, C.-W.; Qi, J.; Iyer, A. M.; He, Y.; Li, Y.; Bardhan, N. M.; Belcher, A. M.*, "Surface plasmon enhanced short-wave infrared fluorescence for detecting submillimeter-sized tumors" Advanced Materials 2021, 33, 2006057
  • Lin, C.-W.; Bachilo, S. M.; Weisman, R. B.*, "Delayed fluorescence from single-walled carbon nanotube through singlet oxygen-sensitized triplet exciton" Journal of the American Chemical Society 2020, 142, 21189
  • Lin, C.-W.; Bachilo, S. M.; Zheng, Y.; Tsedev, U.; Huang, S.; Weisman,R. B.*; Belcher, A. M.*, "Creating fluorescent quantum defects in carbon nanotubes using hyphchlorite and light" Nature Communications 2019, 10, 2874
  • Lin, C.-W.; Bachilo, S. M.; Weisman, R. B.*, "Synchro-excited single photoncounting: A novel method for measuring short-wave infrared emission kinetics"  Analytical Chemistry 2019, 91, 12484
  • Lin, C.-W.; Yang, H.; Sanchez, S. R.; Mao, W.; Pang, L.; Beckingham, K.M.; Bast, R. C.; Weisman, R. B.*, "In vivo optical detection and spectral triangulation of carbon nanotubes" ACS Applied Materials & Interfaces 2017, 9, 41680-41690.
  • Lin, C.-W.; Bachilo, S. M.; Vu, M.; Beckingham, K. M.; Weisman, R. B.*, "Spectral triangulation: A 3D method for locating single-walled carbon nanotubes in vivo" Nanoscale 2016, 8, 10348-10357.