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Chia-Lung Hsieh

Research Fellow / Deputy Director

Chia-Lung Hsieh
Office: R319
Tel: +886-2-2362-4956
Lab: R321
Lab Tel: +886-2-2362-4955
Nano-Bio-Photonics Lab

Research Interest

  • Nanoscale biophysics
  • Quantitative bioanalytical approaches
  • Advanced optical microscopy
  • High-speed optical microscope techniques

Research Overview

Dr. Chia-Lung Hsieh works at the intersection of advanced optical microscopy and nanoscale biophysics, specializing in the development of ultrafast, high-resolution imaging systems that reveal rapid and subtle dynamics inside living cells. The ultrafast microscopy platforms he has developed enable real- time visualization of nanoscale structural changes and dynamic behaviors in the cell membrane and chromatin, providing new insights into mechanisms underlying cellular signaling, gene regulation, and disease progression. His research advances the quantitative measurement of intracellular dynamics and deepens our understanding of the molecular pathology of major biomedical diseases, including cancer, neurodegeneration, and viral infections.

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Education

  • B.S. , 2002, Electrical Engineering, National Tsing Hua University (NTHU), Taiwan
  • M.S., 2004, Electro-Optical Engineering, National Taiwan University (NTU), Taiwan
  • Ph.D., 2011, Electrical Engineering, California Institute of Technology, USA

Professional History

  • 2024 – Present  Research Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica, Taiwan
  • 2025 – Present  Adjunct Professor, Department of Physics, National Taiwan University, Taiwan
  • 2019 – 2024  Associate Research Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica, Taiwan
  • 2022 – 2025  Adjunct Associate Professor, Department of Physics, National Taiwan University, Taiwan
  • 2012 – 2019  Assistant Research Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica, Taiwan
  • 2011 – 2012     Postdoctoral Research Fellow, Max Planck Institute for the Science of Light, Germany

Awards & Honors

  • 2024 The 20th Tien Te Lee Young Investigator Award, Tien Te Lee Biomedical Foundation, Taiwan
  • 2023 Outstanding Award, Chung Hwa Rotary Education Foundation, Taiwan
  • 2022 The 20th Y. Z. Hsu Scientific Paper Award, Far Eastern Y. Z. Hsu Science and Technology Memorial Foundation, Taiwan
  • 2021 The Ta-You Wu Memorial Award, Ministry of Science and Technology, Taiwan
  • 2020 The Young Scholars' Creativity Award, Foundation for the Advancement of Outstanding Scholarship, Taiwan
  • 2019 Junior Research Investigator Award, Academia Sinica, Taiwan
  • 2017 Career Development Award, ​Academia Sinica, Taiwan.​
Selected Publications
  1. Cheng CY, Hsiao YT, Wong KL, Tseng HH, Tsao Y, Hsieh CL*, “Temporal variance mapping with machine learning for label-free 3D chromatin imaging using optical interferometric microscopy,” Biomedical Optics Express 17(2), pp. 527-543 (2026).
  2. Tsai SF, Hsieh CL*, “Ultrasensitive bright-field microscope enables label-free single-protein detection,” Optics Letters, 50(24), pp.7520-7523 (2025).
  3. Brooks NJ, Liu CC, Hsieh CL*, “Point spread function engineering for spiral phase interferometric scattering microscopy enables robust 3D single-particle tracking,” ACS Photonics 11(12), pp. 5239-5250 (2024).
  4. Hsiao YT, Liao IH, Wu BK, Chu HP, Hsieh CL*, "Probing chromatin condensation dynamics in live cells using interferometric scattering correlation spectroscopy," Communications Biology 7: 763 (2024).
  5. Hsiao YT, Tsai CN, Chen TH, Hsieh CL*, "Label-free dynamic imaging of chromatin in live cell nuclei by high-speed scattering-based interference microscopy," ACS Nano 16(2), 2774 (2022).
  6. Huang YC, Chen TH, Juo JY, Chu SW, Hsieh CL*, "Quantitative imaging of single light-absorbing nanoparticles by widefield interferometric photothermal microscopy," ACS Photonics 8(2), 592 (2021).
  7. Liao YH, Lin CH, Cheng CY, Wong WC, Juo JY, Hsieh CL*, "Monovalent and oriented labeling of gold nanoprobes for the high-resolution tracking of a single membrane molecule," ACS Nano 13(10), 10918 (2019).
  8. Cheng CY, Liao YH, Hsieh CL*, "High-speed imaging and tracking of very small single nanoparticles by contrast enhanced microscopy," Nanoscale 11, 568 (2019).
  9. Cheng CY, Hsieh CL*, "Background estimation and correction for high-precision localization microscopy," ACS Photonics 4(7), 1730 (2017).
  10. Huang YF, Zhuo GY, Lin CH, Hsieh CL*, "Label-free, ultrahigh-speed, 3D observation of bidirectional and correlated intracellular cargo transport by coherent brightfield microscopy," Nanoscale 9 6567 (2017).
  11. Huang YF, Zhuo GY, Chou CY, Lin CH, Chang W, Hsieh CL*, "Coherent brightfield microscopy provides the spatiotemporal resolution to study early stage viral infection in live cells," ACS Nano 11(3), 2575 (2017).