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Huan-Cheng Chang

Distinguished Research Fellow

Huan-Cheng Chang
Email: hchang[at]gate.sinica.edu.tw
Office: R337
Tel: +886-2-2366-8260
Lab: 510
Lab Tel: +886-2-2366-8226
Biophysical Chemistry Laboratory

Research Interest

  • Biophysical Chemistry
  • Biomolecular Mass Spectrometry
  • Biophotonics 
  • Quantum Sensing

Research Overview

Dr. Huan-Cheng Chang coined the term "fluorescent nanodiamond (FND)" and pioneered the application of this quantum biomaterial in biomedical research, opening up new fields of clinical applications for nanodiamonds in cell tracking, disease diagnosis, and drug delivery. His developed FND material possesses excellent biocompatibility, stable fluorescence properties, and quantum sensing capabilities, making it an important platform for advanced biomedical imaging technologies. Additionally, Dr. Chang and his team have obtained multiple patents related to fluorescent nanodiamonds in various countries and are actively promoting technology transfer and commercialization. Furthermore, Dr. Chang has authored the book "Fluorescent Nanodiamonds," which systematically organizes the physical properties, preparation methods, and applications of FND materials in the biomedical field, and has been widely cited and praised by the international academic community. He has also published more than 100 high-impact journal articles, covering topics such as nanodiamond synthesis, photophysical properties, quantum sensing, and clinical applications, and has received high attention and recognition in important international journals and academic conferences.

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Education

  • B. S., 1981, National Taiwan University, Taiwan
  • M. S., 1983, National Taiwan University, Taiwan
  • Ph. D., 1990, Indiana University at Bloomington, USA

Professional History

  • 1990–1993, Postdoctoral Fellow, Harvard University, USA
  • 1994–1999, Associate Research Fellow, IAMS, Academia Sinica
  • 1995–1996, Visiting Scientist, University of California at Berkeley, USA
  • 2000–2013, Research Fellow, IAMS, Academia Sinica
  • 2004–2009, Joint Appointment Professor, Department of Chemistry, National Taiwan Normal University
  • 2005–2007, Panel Member, Division of Chemistry, National Science Council
  • 2006–2013, Associate Editor, Journal of the Chinese Chemical Society, Taipei
  • 2007–2012, Joint Appointment Professor, Department of Chemistry, National Taiwan University
  • 2012–2016, Vice Executive Secretary, Central Academic Advisory Committee, Academia Sinica
  • 2013–present, Distinguished Research Fellow, IAMS, Academia Sinica
  • 2014–present, Honorary Chair Professor, Department of Chemical Engineering, National Taiwan University of Science and Technology
  • 2016–present, Joint Appointment Professor, Department of Chemistry, National Taiwan Normal University

Awards & Honors

  • 1998, Academia Sinica Research Award for Junior Researchers
  • 2001, Distinguished Young Researcher Award of Tsing-Hua Foundation of Chemistry Technology
  • 2003–2005, National Science Council Outstanding Research Award
  • 2007–2011, Academia Sinica Investigator Award
  • 2007–2011, Outstanding Scholar Award of Foundation for the Advancement of Outstanding Scholarship
  • 2008, Academic Award of Ministry of Education
  • 2010–2013, Science Vanguard Research Program, National Science Council
  • 2013–2017, Academia Sinica Investigator Award
  • 2014–2017, Science Vanguard Research Program, Ministry of Science and Technology
  • 2014, Best Article Award, Journal of the Chinese Chemical Society, Taipei
  • 2014, Ho Chin Tui Award
  • 2015–2017, Outstanding Research Award, Ministry of Science and Technology
  • 2017, FutureTech Demo and Breakthrough Award, Ministry of Science and Technology
  • 2017, Far Eastern Y. Z. Hsu Chair Professor
  • 2019–2013, Academia Sinica Investigator Award
  • 2019, The Franco-Taiwanese Scientific Grand Prize
  • 2019, National Innovation Award of Taiwan Government
  • 2019, Best Article Award, Journal of the Chinese Chemical Society, Taipei
  • 2020, Outstanding Research Award, Taiwan Nanomedicine Society
  • 2021, National Innovation Excelsior Award of Taiwan Government
  • 2021, Academic Achievement Award, Chemical Society Located in Taipei 
  • 2023, FutureTech Award, National Science and Technology Council 
  • 2024, NSTC Research Fellow
  • 2025, National Innovation Excelsior Award of Taiwan Government
  • 2025, Best Article Award – Journal of the Chinese Chemical Society
Selected Publications
  1. Y. Y. Hui*, Y.-M. Tsui, Y.-X. Tang, and H.-C. Chang*, “Ultrathin fluorescent nanodiamond films for nanoscale quantum sensing in operando semiconductor devices,” Adv. Funct. Mater. 36, e13406 (2026).
  2. T.-I. Yang, Y.-Y. Hui, J.-I. Lo, Y.-W. Huang, Y.-Y. Lee, B.-M. Cheng*, and H.-C. Chang*, “Imaging extreme ultraviolet radiation using nanodiamonds with nitrogen-vacancy centers,” Nano Lett. 23, 9811–9816 (2023).
  3. Y. Y. Hui, O. Y. Chen, H.-H. Lin, Y.-K. Su, K. Chen, C.-Y. Wang, W. W.-W. Hsiao, and H.-C. Chang*, “Magnetically modulated fluorescence of nitrogen-vacancy centers in nanodiamonds for ultrasensitive biomedical analysis,” Anal. Chem. 93, 7140–7147 (2021).
  4. H.-C. Lu*, J.-I. Lo, Y.-C. Peng, S.-L. Chou, B.-M. Cheng*, and H.-C. Chang*, “Nitrogen-vacancy centers in diamond for high-performance detection of vacuum ultraviolet, extreme ultraviolet and X-rays,” ACS Appl. Mater. Interfaces 12, 3847−3853 (2020).
  5. H.-C. Chang, W. W.-W. Hsiao, and M.-C. Su, Fluorescent Nanodiamonds, Wiley (2019) (296pp).
  6. F.-J. Hsieh, Y.-W. Chen, Y.-K. Huang, H.-M. Lee, C.-H. Lin, and H.-C. Chang*, “Correlative light-electron microscopy of lipid-encapsulated fluorescent nanodiamonds for nanometric localization of cell surface antigens,” Anal. Chem. 90, 1566–1571 (2018).
  7. H.-C. Lu*, S.-L. Chou, Y.-C. Peng, J.-I. Lo, B.-M. Cheng*, and H.-C. Chang*, “Far-UV excited luminescence of nitrogen-vacancy centers: Evidence for diamonds in space,” Angew. Chem. Int. Ed. 56, 14469–14473 (2017).
  8. L.-J. Su, M.-H. Wu, Y. Y. Hui, B.-M. Chang, L. Pan, P.-J. Hsu, Y.-T. Chen, H.-N. Ho, Y.-H. Huang, T.-Y. Ling*, H.-H. Hsu*, and H.-C. Chang*, “Fluorescent nanodiamonds enable quantitative tracking of human mesenchymal stem cells in miniature pigs,” Sci. Rep. 7, 45607 (2017) (11pp).  
  9. P.-C. Tsai, C. P. Epperla, J.-S. Huang, O. Y. Chen, C.-C. Wu, and H.-C. Chang*, “Measuring nanoscale thermostability of cell membranes with single gold-diamond nanohybrids,” Angew. Chem. Int. Ed. 56, 3025–3030 (2017).
  10. W. W.-W. Hsiao, Y. Y. Hui, P.-C. Tsai, and H.-C. Chang*, “Fluorescent nanodiamond: A versatile tool for long-term cell tracking, super-resolution imaging, and nanoscale temperature sensing,” Acc. Chem. Res. 49, 400–407 (2016).
  11. Y.-K. Tzeng, P.-C. Tsai, H.-Y. Liu, O. Y. Chen, H. Hsu, F.-G. Yee, M.-S. Chang*, and H.-C. Chang*, “Time-resolved luminescence nanothermometry with nitrogen-vacancy centers in nanodiamonds,” Nano Lett. 15, 3945–3952 (2015).
  12. T.-J. Wu, Y.-K. Tzeng, W.-W. Chang, C.-A. Cheng, Y. Kuo, C.-H. Chien, H.-C. Chang*, and J. Yu*, “Tracking the engraftment and regenerative capabilities of transplanted lung stem cells using fluorescent nanodiamonds,” Nat. Nanotechnol. 8, 682–689 (2013).
  13. V. Vaijayanthimala, P.-Y. Cheng, S.-H. Yeh, K.-K. Liu, C.-H. Hsiao*, J.-I. Chao*, and H.-C. Chang*, “The long-term stability and biocompatibility of fluorescent nanodiamond as an in vivo contrast agent,” Biomaterials 33, 7794–7802 (2012). 
  14. H.-C. Chang, W. Fann, and C.-C. Han, “Luminescent diamond particles,” US Patent 8,168,413 (2012). 
  15. Y.-K. Tzeng, O. Faklaris, B.-M. Chang, Y. Kuo, J.-H. Hsu, and H.-C. Chang*, “Superresolution imaging of albumin-conjugated fluorescent nanodiamonds in cells by stimulated emission depletion,” Angew. Chem. Int. Ed. 50, 2262–2265 (2011).
  16. N. Mohan, C.-S. Chen, H.-H. Hsieh, Y.-C. Wu*, and H.-C. Chang*, “In vivo imaging and toxicity assessments of fluorescent nanodiamonds in Caenorhabditis elegans,” Nano Lett. 10, 3692–3699 (2010).
  17. H.-C. Chang*, “Ultrahigh-mass mass spectrometry of single biomolecules and bioparticles,” Annu. Rev. Anal. Chem. 2, 169–185 (2009).
  18. Y.-R. Chang, H.-Y. Lee, K. Chen, C.-C. Chang, D.-S. Tsai, C.-C. Fu, T.-S. Lim, Y.-K. Tzeng, C.-Y. Fang, C.-C. Han, H.-C. Chang*, and W. Fann*, “Mass production and dynamic imaging of fluorescent nanodiamonds,” Nat. Nanotechnol. 3, 284–288 (2008).
  19. C.-C. Fu, H.-Y. Lee, K. Chen, T.-S. Lim, H.-Y. Wu, P.-K. Lin, P.-K. Wei, P.-H. Tsao, H.-C. Chang*, and W. Fann*, “Characterization and application of single fluorescent nanodiamonds as cellular biomarkers,” Proc. Natl. Acad. Sci. USA 104, 727–732 (2007).
  20. Z. X. Nie, Y.-K. Tzeng, H.-C. Chang*, C.-C. Chiu, C.-Y. Chang, C.-M. Chang, and M.-H. Tao, “Microscopy-based mass measurement of a single whole virus in a cylindrical ion trap,” Angew. Chem. Int. Ed. 45, 8131–8134 (2006).
  21. S.-J. Yu, M.-W. Kang, H.-C. Chang*, K.-M. Chen, and Y.-C. Yu, “Bright fluorescent nanodiamonds: No photobleaching and low cytotoxicity,” J. Am. Chem. Soc. 127, 17604–17605 (2005).
  22. X. L. Kong, L. C. L. Huang, C.-M. Hsu, W.-H. Chen, C.-C. Han, and H.-C. Chang*, “High-affinity capture of proteins by diamond nanoparticles for mass spectrometric analysis,” Anal. Chem. 77, 259–265 (2005).
  23. H.-C. Chang*, C.-C. Wu, and J.-L. Kuo*, “Recent advances in understanding the structures of medium-sized protonated water clusters,” Int. Rev. Phys. Chem. 24, 553–578 (2005).
  24. L. C. L. Huang and H.-C. Chang*, “Adsorption and immobilization of cytochrome c on nanodiamonds,” Langmuir 20, 5879–5884 (2004).
  25. J. C. Jiang, H.-C. Chang, Y.-S. Wang, S. H. Lin, Y. T. Lee, G. Niedner-Schatteburg, and H.-C. Chang*, “Infrared spectra of H+(H2O)5-8 clusters: Evidence for symmetric proton hydration,” J. Am. Chem. Soc. 122, 1398–1410 (2000).
  26. C.-L. Cheng, H.-C. Chang*, J.-C. Lin*, K.-J. Song, and J.-K. Wang, “Direct observation of hydrogen etching anisotropy on diamond single crystal surfaces,” Phys. Rev. Lett. 78, 3712−3716 (1997).
  27. H.-C. Chang*, J.-C. Lin, J.-Y. Wu, and K.-H. Chen, “Infrared spectroscopy and vibrational relaxation of CHx and CDx stretches on synthetic diamond nanocrystal surfaces,” J. Phys. Chem. 99, 11081–11088 (1995).